The potential for these risks should not, however, prevent the proper management of pain in any given patient. Patients at increased risk may be prescribed opioids such as Demerol Injection, but use in such patients necessitates intensive counseling about the risks and proper use of Demerol Injection along with intensive monitoring for signs of addiction, abuse, and misuse. While many dieters swear by high-, eating large amounts of can also cause a stone to form. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Meperidine causes a reduction in motility associated with an increase in smooth muscle tone in the antrum of the stomach duodenum. Digestion of food in the small intestine is delayed and propulsive contractions are decreased. Propulsive peristaltic waves in the colon are decreased, while tone may be increased to the point of spasm, resulting in constipation. Other opioid-induced effects may include a reduction in biliary and pancreatic secretions, spasm of sphincter of Oddi, and transient elevations in serum amylase. Meperidine is metabolized through biotransformation. In vitro data show meperidine is metabolized to normeperidine in liver mainly by CYP3A4 and CYP2B6.
Demerol Injection should not be used for treatment of chronic pain. Other medications can affect the removal of from your body, which may affect how methylprednisolone works. What happens if I miss a dose Detrol? Butorphanol, nalbuphine, pentazocine, buprenorphine.
What other drugs will affect tolterodine Detrol LA? Allergic. Pruritus, urticaria, other skin rashes, wheal and flare over the vein with intravenous injection. If concomitant use cimetidine and Demerol Injection is necessary, monitor patients for respiratory depression and sedation at frequent intervals.
HCl, and it has the following chemical structure. Parenteral drug abuse is commonly associated with transmission of infectious diseases such as hepatitis and HIV. Chronic use of opioids may influence the hypothalamic-pituitary-gonadal axis, leading to androgen deficiency that may manifest as low libido, impotence, erectile dysfunction, amenorrhea, or infertility. Consult your pharmacist for further advice. It is not known whether this drug passes into milk. Consult your doctor before -feeding. It is not known whether tolterodine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. If you are taking this once daily and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Contact local state professional licensing board or state controlled substances authority for information on how to prevent and detect abuse or diversion of this product. You need to get the condition treated. If your bladder can't empty, that can lead to infections and other problems. Overestimating the Demerol Injection dosage when converting patients from another opioid product can result in a fatal overdose with the first dose. Parenteral drug products should be inspected visually for particulate and discoloration prior to administration whenever solution and container permit. RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions. This product may increase your potassium levels. Before using potassium or salt substitutes that contain potassium, consult your doctor or pharmacist. Tell your doctor if your condition persists or worsens.
The opioid antagonists, naloxone or nalmefene, are specific antidotes to respiratory depression resulting from opioid overdose. For clinically significant respiratory or circulatory depression secondary to meperidine overdose, administer an opioid antagonist. Opioid antagonists should not be administered in the absence of clinically significant respiratory or circulatory depression secondary to meperidine overdose. Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. Store at room temperature away from moisture and heat. It repositions the urethra to help reduce leakage. Before you take tolterodine, tell your doctor if you have kidney or liver disease, glaucoma, myasthenia gravis, or a personal or family history of "Long QT syndrome. If your kidney stone is small, you may be able to get rid of it when you pee. You should not take this medication if you are allergic to tolterodine or fesoterodine Toviaz if you have untreated or uncontrolled narrow-angle glaucoma, or if you have a blockage of the urinary tract, stomach, or intestines. Then, if needed, she will order tests to get pictures of your kidneys and urinary tract. Alternatively, consider the use of non-opioid analgesics in these patients. Individually titrate Demerol Injection to a dose that provides adequate analgesia and minimizes adverse reactions. diltiazem
Acute overdose with Demerol Injection can be manifested by respiratory depression, somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, constricted pupils, and, in some cases, pulmonary edema, bradycardia, hypotension, partial or complete airway obstruction, atypical snoring, and death. Demerol Injection may reduce respiratory drive, and the resultant CO 2 retention can further increase intracranial pressure. Monitor such patients for signs of sedation and respiratory depression, particularly when initiating therapy with Demerol Injection. It may be taken with or without food. The dosage is based on your medical condition and response to therapy. Prolonged use of Demerol Injection during pregnancy can result in withdrawal in the neonate. Neonatal opioid withdrawal syndrome, unlike opioid withdrawal syndrome in adults, may be life-threatening if not recognized and treated, and requires management according to protocols developed by neonatology experts. Observe newborns for signs of neonatal opioid withdrawal syndrome and manage accordingly. They also stimulate prolactin, growth hormone GH secretion, and pancreatic secretion of insulin and glucagon. What other drugs will affect tolterodine Detrol? This medication may lower your ability to fight infections. This may make you more likely to get a serious rarely fatal infection or make any infection you have worse. With this type, urine leaks due to weakened pelvic floor muscles and tissues. Methylprednisolone may also be used with other in hormone disorders. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately. FDA pregnancy category C. It is not known whether tolterodine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Check the labels on all your medicines such as allergy or cough-and-cold products because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely. Meperidine causes miosis, even in total darkness. What happens if I overdose Detrol? You'll through this procedure. vytorin purchase europe vytorin
Although may be used to prevent problems or treat people who have problems, it may also rarely cause serious kidney problems or make them worse. Your doctor will check your kidney function while you are taking candesartan. Tell your doctor right away if you have any signs of kidney problems such as a change in the amount of urine. Your doctor may occasionally change your dose to make sure you get the best results. Shock wave lithotripsy: This is the most common procedure for kidney stones in the United States. It uses shock waves, which can blast the stone into little pieces. Then, the smaller pieces can more easily be passed in your urine. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. If you have any questions about Detrol LA extended-release capsules, please talk with your doctor, pharmacist, or other health care provider. Talk to your doctor or about lifestyle changes that might benefit you. Opioids cross the placenta and may produce respiratory depression and psycho-physiologic effects in neonates. An opioid antagonist, such as naloxone, must be available for reversal of opioid-induced respiratory depression in the neonate. Demerol Injection is not recommended for use in pregnant women during or immediately prior to labor, when other analgesic techniques are more appropriate. Opioid analgesics, including Demerol Injection, can prolong labor through actions which temporarily reduce the strength, duration, and frequency of uterine contractions. However, this effect is not consistent and may be offset by an increased rate of cervical dilation, which tends to shorten labor. Monitor neonates exposed to opioid analgesics during labor for signs of excess sedation and respiratory depression. If there's a blockage, you may need surgery.
Opioids are sought by drug abusers and people with addiction disorders and are subject to criminal diversion. Consider these risks when prescribing or dispensing Demerol Injection. Strategies to reduce these risks include prescribing the drug in the smallest appropriate quantity. Follow patients for signs and symptoms of respiratory depression and sedation. What should I discuss with my healthcare provider before taking tolterodine Detrol? Observational studies have demonstrated that concomitant use of opioid analgesics and benzodiazepines increases the risk of drug-related mortality compared to use of opioid analgesics alone. Serious, life-threatening, or fatal respiratory depression may occur with use of Demerol Injection. Detrol LA extended-release capsules may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Detrol LA extended-release capsules with caution. Demerol Injection may impair the mental or physical abilities needed to perform potentially hazardous activities such as driving a car or operating machinery. Warn patients not to drive or operate dangerous machinery unless they are tolerant to the effects of Demerol Injection and know how they will react to the medication. Carpuject are packaged in a Slim-Pak tamper detection package. Note that a needle is not included. Pfizer also has programs that provide eligible patients with insurance, support assistance, and medicines at a savings. Contact Pfizer RxPathways for details 844-989-7284. Check with your pharmacist about how to dispose of unused medicine. Do not increase your dose or take this medication more often than directed. Your condition will not improve any faster and your risk of serious side effects may be increased. Opioids have been shown to have a variety of effects on components of the immune system in in vitro and animal models. The clinical significance of these findings is unknown. Overall, the effects of opioids appear to be modestly immunosuppressive. These are the most common ones. Woosley RL, Romero KA. www. uggus.info propecia
Chronic use of opioids may cause reduced fertility in females and males of reproductive potential. Demerol Injection is indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Tolterodine is used to treat overactive bladder with symptoms of urinary frequency, urgency, and incontinence. Your doctor may want you to save the stone so it can be tested. If she can figure out what kind of stone it is, that may help prevent you from having another one. Lifestyle changes and treatments can help with symptoms. Use Detrol LA extended-release capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions. If you are in really bad pain, you probably want to see a doctor. For certain products of this drug, an empty tablet shell may appear in your stool. This is harmless. Drug-seeking" behavior is very common in persons with substance use disorders. Drug-seeking tactics include emergency calls or visits near the end of office hours, refusal to undergo appropriate examination, testing, or referral, repeated "loss" of prescriptions, tampering with prescriptions, and reluctance to provide prior medical records or contact information for other treating health care providers. "Doctor shopping" visiting multiple prescribers to obtain additional prescriptions is common among drug abusers and people suffering from untreated addiction. Preoccupation with achieving adequate pain relief can be appropriate behavior in a patient with poor pain control. Serotonin syndrome: Cases of serotonin syndrome, a potentially life-threatening condition, have been reported during concomitant use of opioids with serotonergic drugs. Because of these risks, reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate. Methylprednisolone can make you more likely to get infections or may worsen any current infections. Therefore, well to prevent the spread of infection. In patients with pheochromocytoma, meperidine has been reported to provoke hypertension. buy budesonide ontario
Meperidine may enhance the neuromuscular blocking action of skeletal muscle relaxants and produce an increased degree of respiratory depression. Struvite stones: Infections, especially in the urinary tract, can cause you to have this kind of stone. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. Limit dosage and duration to the minimum required.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Have your checked regularly while taking this medication. Learn how to monitor your own pressure at home, and share the results with your doctor. Gastrointestinal. Dry mouth, constipation, biliary tract spasm. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. What should I discuss with my healthcare provider before taking tolterodine Detrol LA? See USP Controlled Room Temperature. Talk to your doctor about using tolterodine safely. drugs like galantamine
Monitor patients for signs of urinary retention or reduced gastric motility when Demerol Injection is used concomitantly with anticholinergic drugs. In clinical studies reported in the literature, changes in several pharmacokinetic parameters with increasing age have been observed. The initial volume of distribution and steady-state volume of distribution may be higher in elderly patients than in younger patients. The free fraction of meperidine in plasma may be higher in patients over 45 years of age than in younger patients. Opioids can reduce the efficacy of diuretics by inducing the release of antidiuretic hormone. Demerol Injection, like other opioids, can be diverted for non-medical use into illicit channels of distribution. Careful record-keeping of prescribing information, including quantity, frequency, and renewal requests, as required by state and federal law, is strongly advised. Overdose symptoms may include dry mouth, blurred vision, and fast heartbeat. Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. Do not share this medication with others. DEMEROL is not a trademark of Hospira. Stopping the flow of urine can lead to an infection. See "What Are Side Effects Associated with Using Tolterodine? The dose should be titrated to the needs of the patient and will depend on the premedication and type of anesthesia being employed, the characteristics of the particular patient, and the nature and duration of the operative procedure. Elderly patients should usually be given meperidine at the lower end of the dose range and observed closely. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. order now dramamine mastercard
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. Cordarone, Pacerone dofetilide Tikosyn disopyramide Norpace procainamide Procan, Pronestyl quinidine Quin-G or sotalol Betapace. Reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate. Limit dosages and durations to the minimum required. This medication may cause to not work as well. Live may cause serious problems such as infection if given while you are using this medication. If concomitant use is necessary, consider dosage reduction of Demerol Injection until stable drug effects are achieved. Monitor patients for respiratory depression and sedation at frequent intervals. This may interfere with certain laboratory tests such as possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug. Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Inform your doctor if your condition persists or worsens. In case of overdose, priorities are the reestablishment of a patent and protected airway and institution of assisted or controlled ventilation, if needed. Employ other supportive measures including oxygen and vasopressors in the management of circulatory shock and pulmonary edema as indicated. Cardiac arrest or arrhythmias will require advanced life-support techniques. Studies in animals to evaluate the mutagenic potential of meperidine have not been conducted. Even if you have a kidney stone, you may not have any symptoms -- that is, until the stone goes on the move. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Injections and surgery. Shots to bulk up your urethral area may help. In more extreme cases, you may need surgery. One procedure pulls the bladder back up to a more normal position, relieving the pressure and leakage.
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Symptoms can vary and can range in severity. What should I avoid while taking tolterodine Detrol? If your symptoms do not improve or if they become worse, check with your doctor. Do not use Demerol Injection in patients taking MAOIs or within 14 days of stopping such treatment. cost droxia contraindicaciones
There is a relationship between increasing meperidine plasma concentration and increasing frequency of dose-related opioid adverse reactions such as nausea, vomiting, CNS effects, and respiratory depression. Consult your doctor for specific advice. Advise both patients and caregivers about the risks of respiratory depression and sedation when Demerol Injection is used with benzodiazepines or other CNS depressants including alcohol and illicit drugs. Advise patients not to drive or operate heavy machinery until the effects of concomitant use of the benzodiazepine or other CNS depressant have been determined.
This means you may dribble urine. Dosage should be adjusted according to the severity of the pain and the response of the patient. While subcutaneous administration is suitable for occasional use, intramuscular administration is preferred when repeated doses are required. If intravenous administration is required, dosage should be decreased and the injection made very slowly, preferably utilizing a diluted solution. Accumulation of normeperidine as in chronic use or possibly following introduction of a concomitant CYP3A4 inducer presents as excitatory syndrome including hallucinations, tremors, muscle twitches, dilated pupils, hyperactive reflexes, and convulsions. meloxicam
About FAERS: The FDA Adverse Event Reporting System FAERS is used by FDA for activities such as looking for new safety concerns that might be related to a marketed product, evaluating a manufacturer's compliance to reporting regulations and responding to outside requests for information. Reporting of adverse events is a voluntary process, and not every report is sent to FDA and entered into FAERS. This medicine may cause bleeding. Daily use of alcohol while using this medicine may increase your risk for stomach bleeding. Meperidine is contraindicated in patients who are receiving monoamine oxidase MAO inhibitors or those who have recently received such agents. Therapeutic doses of meperidine have occasionally precipitated unpredictable, severe, and occasionally fatal reactions in patients who have received such agents within 14 days. The mechanism of these reactions is unclear, but may be related to a preexisting hyperphenylalaninemia. Some have been characterized by coma, severe respiratory depression, cyanosis, and hypotension, and have resembled the syndrome of acute narcotic overdose. Serotonin syndrome with agitation, hyperthermia, diarrhea, tachycardia, sweating, tremors and impaired consciousness may also occur. In other reactions the predominant manifestations have been hyperexcitability, convulsions, tachycardia, hyperpyrexia, and hypertension.